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Coverage also depends heavily on the medications approved use

49 mtDNA point mutations and deletions increase exponentially with age, disrupt the assembly of the oxidative phosphorylation complex, reduce adenosine triphosphate (ATP) and increase electron leakage, and form a vicious cycle of ROS-damage-ROS

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Deficient endoplasmic reticulum acetyl-CoA import in pancreatic acinar cells leads to chronic pancreatitis

Wu X, Prasad PD, Leibach FH, Ganapathy V